Amitriptyline
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3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,
N-dimethyl-1-propanamine
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CAS number
549-18-8
| ATC code
N06AA09
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| Chemical formula
| C20H23N
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| Molecular weight
| 277.403 g/mol
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| Bioavailability
| 40%
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| Metabolism
| Hepatic
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| Elimination half-life
| 12-24 hours
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| Excretion
| Renal
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| Pregnancy category
| ?
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| Legal status
| ?
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| Routes of administration
| Oral
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Amitriptyline hydrochloride is an antidepressant drug from the tricyclic antidepressant group, which is sold under the trade names Elavil®, Tryptanol® or Endep®.
It is a white, odorless, crystalline compound which is freely soluble in water. It is usually dispensed in tablet form. The empirical formula of its hydrochloride salt is C20H23N·HCl.
Contents
- 1 Mechanism of Action
- 2 Uses
- 2.1 Approved
- 2.2 Unapproved/Off-Label/Investigational
- 3 See also
- 4 References
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Mechanism of Action
Amitriptyline affects serotonin and noradrenaline reuptake almost equally.
Uses
Approved
Amitriptyline is approved for the treatment of endogenous depression and involutional melancholia (depression of late life, which is no longer seen as a disease in its own right),[1] and reactive depression and for depression secondary to alcoholism and schizophrenia.
Unapproved/Off-Label/Investigational
Amitriptyline may be prescribed for other conditions such chronic pain, fibromyalgia or irritable bowel syndrome.
A randomized controlled trial published in June of 2005 found that amitriptyline was effective in functional dyspepsia refractory to famotidine and mosapride combination therapy.[2]
See also
- Antidepressant
- Tricyclic antidepressant
References
- PubChem Substance Summary: Amitriptyline National Center for Biotechnology Information.
- TREPILINE®-10 TABLETS; TREPILINE®-25 TABLETS South African Electronic Package Inserts. 12 May 1978. Revised February 2004.
- SAROTEN® RETARD 25 mg Capsules; SAROTEN® RETARD 50 mg Capsules South African Electronic Package Inserts. December 1987. Updated May 2000.
- ^ Weissman MM. "The myth of involutional melancholia." Journal of the American Medical Association. 1979 Aug 24-31;242(8):742-4. PMID 459064
- ^ Otaka M, Jin M, Odashima M, Matsuhashi T, Wada I, Horikawa Y, Komatsu K, Ohba R, Oyake J, Hatakeyama N, Watanabe S. "New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline." Alimentary Pharmacology & Therapeutics. 2005 Jun;21 Suppl 2:42-6. PMID 15943846 Fulltext
| Antidepressants edit
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| Dopamine reuptake inhibitors edit
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{Bupropion}
{Amineptine}
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| Norepinephrine reuptake inhibitors edit
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{Atomoxetine}
{Reboxetine}
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| Monoamine oxidase inhibitors edit
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{Ayahuasca}
{Nialamide}
{Selegiline}
{Isocarboxazid}
{Iproniazide}
{Iproclozide}
{Moclobemide}
{Phenelzine}
{Toloxatone}
{Tranylcypromine}
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| Selective serotonin reuptake inhibitors edit
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{Alaproclate}
{Etoperidone}
{Citalopram}
{Escitalopram}
{Fluoxetine}
{Fluvoxamine}
{Paroxetine}
{Sertraline}
{Zimelidine}
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|
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Serotonin-norepinephrine reuptake inhibitors edit
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{Desipramine}
{Duloxetine}
{Milnacipran}
{Nefazodone}
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| Selective serotonin reuptake enhancers edit
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{Tianeptine}
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| Tetracyclic antidepressants [ edit ]
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{Maprotiline}
{Mianserin}
{Mirtazapine}
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| Bicyclic antidepressants edit
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{Viloxazine}
{Venlafaxine}
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| Tricyclic antidepressants [ edit ]
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{Amitriptyline}
{Amoxapine}
{Clomipramine}
{Desipramine}
{Dothiepin}
{Doxepin}
{Imipramine}
{Lofepramine}
{Nortriptyline}
{Protriptyline}
{Trimipramine}
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ru:Амитриптилин
Search Term: "Amitriptyline"
Categories: Tricyclic antidepressants | Analgesics |
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Amitriptyline news and Amitriptyline articles Here's our
top rated Amitriptyline links for the day:
Judge Allows Coroner's Statement
The Morning News - Mar 20 12:33 AM BENTONVILLE -- Statements Benton County Coroner Kimberly Scott made from inside a patrol car the night of her arrest on drug and theft charges are admissible in court, a judge ruled Monday.Save
Judge Unseals Coroner Motion
The Morning News - Mar 20 12:35 AM BENTONVILLE -- A sealed motion filed last year in the drug and theft case against Benton County Coroner Kimberly Scott asked Senior Circuit Judge Tom Keith to step down from the case because Scott's attorney is a member of the state panel that investigates complaints against judges -- and Keith had three active complaints against him.Save
Prosecutor, Coroner's Attorney Face Off Monday
The Morning News - Mar 13 12:37 AM BENTONVILLE --Because Coroner Kimberly Scott has a legal right to seize medications from the homes of deceased persons, is she immune from being searched -- or arrested -- if she mishandles them?Save
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